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The clinical payoff of this dual mechanism was established in the SURMOUNT-1 trial, a phase 3 randomized, double-blind, placebo-controlled study of 2,539 adults with obesity or overweight without diabetes

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doi: 10.1016/S1474-4422(10)70116-2 35 Da CruzSParonePALopesVSLilloCMcAlonis-DownesMLeeSKet al

Compounded semaglutide is the cheapest GLP-1 overall , starting as low as $139/month through telehealth providers like Eden, MEDVi, and TrimRx

And so, GLP-1 receptor agonists improve blood glucose control directly by promoting insulin secretion and indirectly by facilitating weight loss