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However, with significant weight loss comes an increased need for nutritional guidance to help patients maintain quality of life and avoid nutritional deficiencies commonly observed during caloric restriction

Bodybuilders trying to boost their muscle mass and biohackers seeking to optimize their health and longevity have used synthetic peptides for years

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The drug, used alongside a reduced calorie diet and increased physical activity, was the first approved drug for chronic weight management in adults with obesity or who are overweight since 2014

The SMART trial Published in Nature Medicine in 2024, it tested semaglutide 2.4 mg specifically in 101 people with CKD and obesity, without diabetes