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Because the researchers found that low birthweight was more common among women who used e-cigarettes frequently than among occasional users, it is possible that the amount of nicotine exposure is linked with these harmful effects

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To ensure the accuracy of this certification, however, the Commission requests comment on whether the proposed rule will have a significant impact on a substantial number of small entities, including specific information on the number of entities that would be covered by the proposed rule, the number of these companies that are small entities, and the average annual burden for each entity