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The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency

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Bulletin of Experimental Biology and Medicine, 119 , 352-355

Antibody-drug conjugates (ADCs) Beta-microglobulin (B2M) To improve the efficiency of senolytics, a new approach is urgently needed to eliminate senescent cells and fight age-related diseases

In cases of acute symptoms and disease progression, surgical treatment is recommended