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519,520 Microglia in aged human brain show substantial morphofunctional deterioration with ~ 40% of all microglial cells becoming morphologically dystrophic and functionally asthenic

Primary Handling Editor: Jerome Staal, in collaboration with the Nature Medicine team

A recent elegant study also found that brain- Gipr knockout mice and humanised ( h ) GIPR knock-in mice with brain- hGIPR deletion showed decreased body weight and improved glucose metabolism [70]

Leaky gut plagues many autoimmune patients and addressing leaky gut is integral to managing autoimmunity

One study found that low homocysteine is associated with idiopathic peripheral neuropathy, a condition that damages nerves.6 This makes sense, as the body needs homocysteine to produce glutathione, which supports the nerves healthy response to oxidative stress