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Taken together, these preclinical data support interventions that target UA to counteract oxidative stress in the ischemic penumbra and protect endothelial cell function after cerebral ischemia-reperfusion injury

Metronidazole (Rozex, Metrogel) Mild anti-inflammatory but less effective than azelaic acid or ivermectin

NAD+ (nicotinamide adenine dinucleotide) is a vitamin-like molecule found in all living cells

Treatment Innovation: Some newer formulations like SmartLotion combine low-dose hydrocortisone with sulfur prebiotics to address both inflammation and microbial imbalance

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