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The search strategy utilized combinations of the following Medical Subject Headings (MeSH) and text words: (gut microbiota OR gastrointestinal microbiome OR dysbiosis) AND (osteoporosis OR bone metabolism OR bone mineral density OR osteoclast OR osteoblast) AND (short-chain fatty acids OR immune regulation OR gut-bone axis OR mechanostat)

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Genetic and epigenetic mechanisms of epilepsy: a review

Furthermore, metformin activates AMPK, which phosphorylates nuclear receptor TR4 to prevent its transcriptional activation, inhibiting the expression of the TR4-mediated gene for coenzyme A dehydrogenase-1 [32]