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Our study places Gsta4 as a key regulator of OL differentiation and remyelination in the context of cellular stress, ageing and demyelination in an experimental setting

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The cultured SGNs were exposed to 100 M peroxynitrite for 48 h (Figure 2C) and immunostaining illustrated that the fluorescence intensity of GPX1 in the peroxynitrite group was significantly reduced compared with that of the control group (Figure 2D)