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Patients with more advanced CKD have been underrepresented in previous trials and effect of GLP-1RA on albuminuria in ESKD not yet shown to translate into reduced risk in these patients[52]

This is especially important because a lot of people carrying extra weight also have excess fat built up in and around the liver (sometimes called fatty liver), which can cause its own health problems

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Studies from the US Food and Drug Administration (FDA) have found a disproportionate reporting of suicidal ideation and depression/suicidal thoughts with semaglutide and liraglutide, but not for suicidal behaviour, suicide attempts and completed suicide [27,28,29,30]

In patients with prostate cancer, elevated levels of Bacteroides massiliensis and significantly lower levels of Eubacterium rectale and Faecalibacterium prausnitzii have been detected, indicating these particular microbes may play a role in the etiology of prostate cancer (168)