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patients monitoring at home may notice lower morning readings Weeks 412: Progressive improvement in overall glycaemic control as steady-state drug levels are achieved and dose titration continues Week 1216: First HbA1c measurement typically shows significant reductionclinical trials demonstrate average HbA1c reductions of 1.01.5% (1116 mmol/mol) with most GLP-1 medications, though individual results vary Months 612: Continued optimisation of glucose control