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Firstly, the liver is critical in synthesizing L-carnitine and, if diseased, L-carnitine biosynthesis is reduced which may affect whole body fatty acid metabolism

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Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

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Sp treatment resulted in presence of ~270 rhabdomeres close to mean wild type number of 290, an improvement over ~200 rhabdomeres observed in the mutants (Fig