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Studying GLP-1, GIP, and glucagon triple RA for the treatment of MASLD/MASH follows the success of mono- and dual-agonists helping patients with type 2 diabetes and obesity achieve clinical targets by offering advantages of each constitutive component while minimising the risk of undesirable effects

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An exploratory analysis of genetic data of patients from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial showed that different haplotypes encoding for GLP-1R correlated with variable response rates to antipsychotic medications 132

10.1074/jbc.M109.062844 122 TraversoN.RicciarelliR.NittiM.MarengoB.FurfaroA