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This population already uses NAD+ boosters, practices time-restricted eating, tracks biomarkers, and views cutting-edge supplementation as part of a comprehensive healthspan extension strategy

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In summary, UPFs may have the potential to elicit addiction-like responses through overstimulation of dopaminergic reward pathways, which may lead to a downregulation of D2 receptors

Supplements never replace prescribed care

In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]