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The evidence base here is thin and largely theoretical, but the concept aligns with established pharmacology of intranasal peptide delivery systems used for other compounds

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They concluded that the net price of Zepbound would have to come down by 31% and the net price of Wegovy would have to come down by 82% for these drugs to be cost-effective at $100,000 per QALY

Figure 1: Changes in gross morphological scores amongst the four experimental treatment groups