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Significantly, vitamin B12 concentrations imply the levels of vitamin B12 in the circulation, and higher levels of serum vitamin B12 may not be directly caused by a higher intake, instead the dysregulation of the metabolism of this vitamin may contribute to higher levels of vitamin B12 in the circulation

This hypothesis was tested through in vivo and in vitro studies

van Ommen B, den Besten C, Rutten AL, Ploemen JH, Vos RM, Muller F, van Bladeren PJ: Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone

Some patients start weekly, then move to monthly maintenance

Moreover, ectopic expression of HFD-TAF12L partially rescued the TAF12 depletion phenotype, mimicking full-length full length TAF12L (Figure 3A