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The STEP 1 trial demonstrated that participants using a GLP-1 receptor agonist achieved a mean weight loss of approximately 14.9% of their body weight over 68 weeks, which is remarkable by any clinical standard (Wilding et al

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Moreover, alterations in the gut microbiota as described in mice require careful analysis in human studies including the assessment of a possible growth advantage for pathogenic bacteria as part of a commensal microbiome or with respect to systemic effects and clinical relevance

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