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The power of fluorescence at the single molecule level was demonstrated in 2000 by Zhuang et al., who showed that fluorescence self-quenching (i.e., fluorescence quenching between identical fluorophores) is sensitive to the collapse of intrinsically disordered protein titin (Zhuang et al., 2000)

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Male SKO mice displayed significantly enlarged pancreases when compared to WT mice, but this was not altered by liraglutide treatment ( Figure 4D )