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However, frequent spikes and dips in glucose levels, even within the normal range, can lead to inflammation, weight gain, insulin resistance, and increased risk for conditions like cardiovascular disease, type 2 diabetes, Alzheimers disease, and more

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These reactions, mediated by reactive nitrogen species (RNS), further reduce NO availability, ultimately worsening endothelial dysfunction and impairing vasorelaxation [39]

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However, long-term glycemic control decreases the risk of diabetic retinopathy and neuropathy