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This class shares some functional similarities with sulfonylureas, as meglitinides stimulate insulin release from pancreatic beta cells

doi:10.1016/j.soard.2022.08.013 Balasubaramaniam V, Pouwels S

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The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]

We will not prescribe these medications if anyone in your family has had MTC or an endocrine system condition called MEN 2.