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Unlike TRANSCEND-T2D-1, which specifically targeted a diabetes population, TRIUMPH-2 is a weight management basket trial where participants also have T2D a distinct enrollment design

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A Mayo Clinic study in The Lancet [1] (2025) followed 400 postmenopausal women on tirzepatide for 12+ months: HRT + tirzepatide: 17% total body weight loss Tirzepatide alone: 14% or 35% less 45% of HRT users achieved 20% weight loss vs