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In clinical trials, patients on high-dose semaglutide (Wegovy) lost around 15% of their body weight on average over about 16 months, and those on tirzepatide lost 1522% of their weight over about 72 weeks (approximately a year and a half) [utswmed.org]

GSL2 expression is responsible for p53-mediated oxygen consumption, mitochondrial respiration, and adenosine triphosphate production in cancer cells (Hu et al., 2010

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Researchers note that fat loss naturally leads to some muscle reduction, but potential strength loss could be concerning for older adults, whose mobility and quality of life depend on muscle function

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