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BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations

Tirzepatide is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg and gradually increasing by 2.5 mg every 4 weeks as tolerated to a maintenance dose ranging from 5 mg to 15 mg, depending on individual response and tolerability

There are several phase 3 trials evaluating GLP-1s for indications, such as metabolic dysfunction-associated steatohepatitis (MASH), prediabetes, Alzheimer's disease, diabetic retinopathy, and osteoarthritis of the knee (in patients with obesity)

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The bottom line is this: Ozempic works by slowing the passage of everything through the digestive system and that includes any pills taken by mouth