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In brief, ovaries were minced, the naked oocytes [germinal vesicle (GV) stage] were collected under the microscope and washed three times in M2 medium (Sigma, M7167)

In the TRIUMPH-4 Phase 3 trial, the most common adverse events for the 12 mg dose were nausea (43.2%), diarrhea (33.1%), constipation (25.0%), vomiting (20.9%), and decreased appetite

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