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Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance

Definitive evidence of the role of FFAs in GH-mediated insulin resistance was obtained in clinical studies in which the effects of exogenously administered GH on insulin resistance were abrogated by Acipimoxan inhibitor of lipolysis [185, 190, 191]

A similar trial also showed faster angiogenesis with a week of injections in lab animals

Critically, these findings remain largely confined to cellular and in vitro models