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A different study found a significant reduction in pore size via a dermatoscopic analyzer after 60 women applied tretinoin 0.025% cream once daily for 90 days.[28] While the direct relationship between pore size and sebum production makes this interesting, one cannot conclude that topical retinoids decrease sebum production given that studies have not distinctly uncoupled this association

Studies have observed interactions between GLP-1 receptor pathways and the hypothalamic-pituitary-adrenal (HPA) axis, hinting at potential roles in modulating cortisol levels, feeding behavior under stress, and central energy-sensing mechanisms

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