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High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15

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When the LC and ALC results were considered together, the ROC analysis showed that the AUC of patients with MDD and HC was 0.891, the sensitivity was 82.0%, and the specificity was 82.0%