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Moreover, using mutant GLP-1Rs, Ge et al (26) described that even with a mutation of the putative signal sequence, ligand binding to the mutant receptor was observed with conserved cAMP production

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The most common side effects were mild to moderate gastrointestinal issues, with about one-third of patients on the highest orforglipron dose experiencing nausea and about one-quarter experiencing constipation or diarrhea