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It was first isolated and characterised by Professor Predrag Sikiric and his research group at the University of Zagreb in the early 1990s, with the foundational paper published in the Journal of Physiology (Paris) in 1993
Research has shown protective effects against age-related changes in retinal tissue and potential benefits for neurodegenerative conditions
Vascular protection: superoxide dismutase isoforms in the vessel wall
doi: 10.1007/s00394-020-02383-1
Progress should be assessed through body composition analysis, circumference measurements, and photos rather than scale weight alone, as muscle preservation can mask fat loss on the scale
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