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Inhibition of DPP4 has been shown to increase Th2 cytokines, restore the balance between Tregs and Th17 cells, and reduce Th1 response

Every pound of muscle you lose reduces your resting metabolic rate, making it harder to maintain weight loss long-term and increasing the likelihood of regain when you eventually stop or reduce your medication

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Plutzky J, Garber A, Falahati A, Toft AD, Poulter NR

Amgens strategy hinges on offering a novel mechanism of action and more convenient dosing schedules, aiming to carve out a competitive niche in the burgeoning weight-loss drug market