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They often require vastly different treatment because of their dynamic physiology that affects the pharmacokinetics (PK), including absorption, distribution, metabolism, and excretion (ADME) of many drugs

R.LvL.et al (2022)

It was shown that a 2 M concentration of RSL3 caused cell death (Su et al., 2020)

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726 Consistent with clinical observations, unilateral, transient middle cerebral artery occlusion/reperfusion (MCAO/R) caused a significant increase in free iron levels, or ferritin levels, in the brains of mice