In mammals there is little evidence that estradiol impacts on neuronal or glial proliferation in developing brain, and there is some clear evidence that it definitely does not (105, 159, 234), but the possibility cannot be entirely ruled out
Morrison JP, Coleman MC, Aunan ES, Walsh SA, Spitz DR, Kregel KC (2005) Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress
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Thus, for these peptides, progress may require further efforts
PLoS ONE 9 , e86515 (2014)