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Highly reactive carbonyl products derived from oxidation of polyunsaturated fatty acids in cell membranes are the most relevant endogenous source (21)

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And emerging data suggest that optimizing the hormonal environment during the menopausal transition more broadly may positively influence weight loss trajectories and body composition outcomes during GLP-1 treatment [17], consistent with the mechanistic picture of restored hormonal signaling creating a more metabolically receptive physiological state

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