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Placebo at 24 weeks Nausea incidence / most common AE / 40.4% in the Phase 3 RECONNECT trial at the approved 1.75 mg dose FDA approval year / Vyleesi / approved June 2019 for premenopausal women with HSDD Contraindication / cardiovascular disease / avoid in patients with known CV disease due to pressor effect Reporting / adverse events / call Poison Control 1-800-222-1222 or go to the nearest emergency department What PT-141 (Bremelanotide) Is and How It Works PT-141, sold as Vyleesi, is a cyclic heptapeptide melanocortin receptor agonist approved by the FDA in June 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women

10.1046/j.1365-2982.1997.d01-26.x 55