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If you experience significant nausea during dose escalation, the standard approach is to hold at the current dose for an additional two to four weeks before attempting the next increase

however, pharmacokinetic interactions and safety considerations must be rigorously assessed

Extended Data Figure 9 Potential NTDtransmembrane bundle interaction, orthosteric agonist binding pocket in GLP-1R and 2 AR

For patients on warfarin, INR monitoring should continue per the prescribing physician's recommendations, with potential for increased frequency during semaglutide initiation or dose changes

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