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Home freezers do not provide the controlled conditions of pharmaceutical freeze-drying

Multivariate analysis (Table 2) shows that TxNIP ( P =0.017, hazard ratio (HR)=0.3, 95% confidence interval (CI)=0.10.8) and thioredoxin reductase ( P =0.022, HR=0.3, 95% CI=0.10.8) are independent factors

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While nausea and vomiting commonly develop early in APAP poisoning, patients who ingest fatal doses may suffer no symptoms until the onset of symptomatic liver failure, which can occur 1 to 4 days later