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The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)

Reversal of chemically induced deficits: Rodents given Dihexa reversed scopolamine-induced water-maze impairment in the 2013 characterization work a paper now under a Notice of Concern [1] [2]

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