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One of the first pathophysiological observations was the increased intestinal permeability in all subtypes of the disease (6163) seen mostly in the diarrhea-predominant IBS (IBS-D) subgroup (64, 65)

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Mechanism of action Acitretin exerts its effects by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), leading to gene transcription changes that mediate its anti-proliferative and anti-inflammatory properties

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