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A 2022 systematic review and meta-analysis in JAMA Internal Medicine found increased rates of gallbladder or biliary disease among GLP-1 receptor agonist users compared to placebo or active comparators, with higher risk at weight-loss doses

The therapeutic potential of GLP-1 receptor agonists in the management of hidradenitis suppurativa: a systematic review of anti-inflammatory and metabolic effects

They were also 29% more likely to experience hypertensive disorders during pregnancy, which are cases of high blood pressure that can exist before pregnancy or develop during it